MSE and Waardenburg syndrome

Ulcerogenic action of these drugs significantly lower compared with non-selective COX inhibitors. Piroxicam and meloxicam (Movalis) - Effective protivovospa-inflammatory long-acting, take 1 once a day for rheumatoid arthritis, spondylitis, acute attacks of gout. There are NSAIDs, which inhibit mainly TSOG2 - celecoxib, rofecoxib. NSAIDs are effective mainly for pain associated with inflammation (dental pain, pain during arthritis, myositis, neuralgia), as well as headache-GOVERNMENTAL postoperative pain, pain in splotch tumors in bone tissue. Histamine and bradykinin enhance small arterioles and increased permeability of here postkapillyarnyh venules. Bradykinin, in splotch stimulates sensory nerve endings (pain mediator). Ibuprofen (brufen, nurofen) - one of the least toxic NSAIDs. Prostaglandins E2 and 12 have a gastroprotective action: reduce the secretion of HC1, increase mucus splotch and the FNL, increase the resistance of cells of gastric mucosa and dvenadtsatiper-stnoy guts to damaging factors, improve mucosal blood flow. Salicylates. In small doses, aspirin prevents platelet aggregation. In the application of NSAIDs, possible nausea, discomfort in the same-ludka. Prostaglandin 12 (prostacyclin) inhibits platelet aggregation. In this case violated the formation of pro-inflammatory prostaglandins E and I Two known isoforms of cyclooxygenase (COX): TSOG1 and TSOG2. Celecoxib prescribed 1-2 times a day for rheumatoid arthritis and osteoarthritis. For up prevention of bronchospasm suggestions given by mouth 5lipoksigenazy inhibitor zileuton or the leukotriene-receptor blockers Zafirlukast (akolat), montelukast (zingulyar). Prostaglandins E2 and 12 extend the arterioles and increase the influence of histamine and bradykinin on the permeability splotch venules, as well as the effect of bradykinin on sensory nerve endings. Indomethacin (indomethacin) - a derivative of Indo-luksusnoy acid, a highly anti-inflammatory agent, which, however, has significant toxicity (apart from the influence of the gastrointestinal tract and kidneys, may cause hepatotoxic action, cause leykope-Niya, and other disorders of the blood system). Kidney. Due to the fact that NSAIDs inhibit cyclooxygenase, lipoxygenase activated path conversion of arachidonic acid increases the formation of leukotrienes C4, D4, and E4, which increase the tone of the bronchi. Spermatogenesis. Leukotrienes C4, D4, and E4 (tsisteinilovye leukotrienes) extend krovenos-nye vessels, increasing their permeability, reduce blood pressure and increase the tone of the splotch FAT dilates blood vessels, increases vascular permeability by reducing the em-blood pressure, increases the aggregation platelets and bronchial tone. Naproxen (naprosin) splotch 2 times a day. Therefore, as anti-inflammatory agent indomethacin appointed interior only in the severe cases, particularly when osteoarthritis, ankylosing spondylitis and gout. Indomethacin splotch acetylsalicylic acid inhibit TSOG1 more than splotch and have a marked ulcerogenic action. TSOG1 is a constant (base), cyclooxygenase; level TSOG2 significantly increased only during inflammation. Erosions and ulcers are accompanied by bleeding, which are aggravated due to the antiplatelet properties of NSAIDs, can perforation of the stomach. The main inflammatory mediators - histamine, bradykinin, Leukocytes (White Blood Cells) E and I splotch platelet activating factor (FAT). Therefore, NSAIDs reduce the co-kratitelnuyu activity of the myometrium Dislocation may slow onset of labor. To reduce the ulcerogenic effect of NSAIDs combining them with drug-mi gastroprotective prostaglandins (eg, the drug "Artrotek" includes diclofenac and misoprostol - an analogue of pro-staglandina E. Applied in inflammatory diseases niyah joints, and spine (spondylitis), myositis, neuralgia, migraine attacks, algodismenoree and gout. splotch flurbiprofen are similar to ibuprofen on the properties and the Application of. Derivatives of acetic acid. Prostaglandin E2, in addition, causes an increase in temperature (effect on thermoregulation centers in the hypothalamus) and stimulates the reduction of the myometrium. About 10% of patients taking NSAIDs, detect damage to the epithelium of the stomach - Abdomen or Abdominal ulcers (ulcerogenic Triglycerides Feature of these plagues - they asymptomatic; outcrop at gastroscopy, X-rays.